ng0106_largecoverF1.mediumJournal of Proteome Research8.cover


  • Legoy TA, Vethe H, Abadpour S, Strand BL, Scholz H, Paulo JA, Raeder H, Ghila L, Chera S: Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling. Sci Rep 2020;10:414


  • Furuyama, K., S. Chera, L. van Gurp, D. Oropeza, L. Ghila, N. Damond, H. Vethe, J. A. Paulo, A. M. Joosten, T. Berney, D. Bosco, C. Dorrell, M. Grompe, Raeder, B. O. Roep, F. Thorel and P. L. Herrera (2019). “Diabetes relief in mice by glucose-sensing insulin-secreting human alpha-cells.” Nature 567(7746): 43-48.
  • Ng NHJ, Jasmen JB, Lim CS, Lau HH, Krishnan VG, Kadiwala J, Kulkarni RN, Raeder H, Vallier L, Hoon S, Teo AKK: HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells. iScience 2019;16:192-205
  • Vethe H, Ghila L, Berle M, Hoareau L, Haaland OA, Scholz H, Paulo JA, Chera S, Raeder H: The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation. Front Endocrinol (Lausanne) 2019;10:293
  • Bjørlykke Y, Søviknes AM, Hoareau L, Vethe H, Mathisen AF, Chera S, Vaudel M, Ghila L and Ræder H. Reprogrammed cells display distinct proteomic signatures associated with colony morphology variability”. Stem Cells Int 2019;2019:8036035
  • Legoy TA, Ghila L, Vethe H, Abadpour S, Mathisen AF, Paulo JA, Scholz H, Raeder H, Chera S: In vivo hyperglycaemia exposure elicits distinct period-dependent effects on human pancreatic progenitor differentiation, conveyed by oxidative stress. Acta Physiol (Oxf) 2019:e13433
  • Loo LSW, Vethe H, Soetedjo AAP, Paulo JA, Jasmen J, Jackson N, Bjorlykke Y, Valdez IA, Vaudel M, Barsnes H, Gygi SP, Raeder H, Teo AKK, Kulkarni RN: Dynamic proteome profiling of human pluripotent stem cell-derived pancreatic progenitors. Stem Cells 2019


  • The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. Johansson BB, Fjeld K, El Jellas K, Gravdal A, Dalva M, Tjora E, Ræder H, Kulkarni RN, Johansson S, Njølstad PR, Molven A. Pancreatology. 2018 Jan;18(1):12-19 Epub 2017 Dec 5. Review. doi: 10.1016/j.pan.2017.12.001. PMID: 29233499
  • Springboard to an academic career-A national medical student research program. Jacobsen GW, Ræder H, Stien MH, Munthe LA, Skogen V. PLoS One. 2018 Apr 30;13(4):e0195527. doi: 10.1371/journal.pone.0195527. PMID: 29708980


  • Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells. Vethe H, Bjørlykke Y, Ghila LM, Paulo JA, Scholz H, Gygi SP, Chera S, Ræder H. Scientific Reports. 2017 Jul 6;7(1):4780. doi: 10.1038/s41598-017-04979-w. PMID: 28684784
  • Anatomy and evolution of database search engines — a central component of mass spectrometry based proteomic workflows. Verheggen K, Raeder H, Berven FS, Martens L, Barsnes H, Vaudel M. Mass Spectrom Rev. 2017 Sep 13. doi: 10.1002/mas.21543
  • The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. Johansson BB, Fjeld K, El Jellas K, Gravdal A, Dalva M, Tjora E, Ræder H, Kulkarni RN, Johansson S, Njølstad PR, Molven A. Pancreatology. 2017 Dec 5. pii: S1424-3903(17)30890-6. doi: 10.1016/j.pan.2017.12.001.


  • Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. Teo AK, Lau HH, Valdez IA, Dirice E, Tjora E, Raeder H, Kulkarni RN. Stem Cell Reports. 2016 Feb 8. pii: S2213-6711(16)00024-2. doi: 10.1016/j.stemcr.2016.01.007. PMID: 26876668

  • Using Proteomics Bioinformatics Tools and Resources in Proteogenomic Studies. Vaudel M, Barsnes H, Ræder H, Berven FS. Adv Exp Med Biol. 2016;926:65-75. PMID: 27686806

  • Systemic Analysis of Regulated Functional Networks. Hernández Sánchez LF, Aasebø E, Selheim F, Berven FS, Ræder H, Barsnes H, Vaudel M. Methods Mol Biol. 2016;1394:287-310. doi: 10.1007/978-1-4939-3341-9_21. PMID: 26700057

  • Hereditary hypophosphatemia in Norway: a retrospective population-based study of genotypes, phenotypes, and treatment complications. Rafaelsen S, Johansson S, Ræder H, Bjerknes R. Eur J Endocrinol. 2016 Feb;174(2):125-36. doi: 10.1530/EJE-15-0515. PMID: 26543054
  • Exploring the potential of public proteomics data. Vaudel M, Verheggen K, Csordas A, Raeder H, Berven FS, Martens L, Vizcaíno JA, Barsnes H. Proteomics. 2016 Jan;16(2):214-25. doi: 10.1002/pmic.201500295. PMID: 26449181


  • The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey). Helgeland Ø, Hertel JK, Molven A, Ræder H, Platou CG, Midthjell K, Hveem K, Nygård O, Njølstad PR, Johansson S. Int J Endocrinol. 2015;2015:164652. doi: 10.1155/2015/164652. PMID: 26089876

  • Carboxyl-ester lipase maturity-onset diabetes of the young disease protein biomarkers in secretin-stimulated duodenal juice. Bjorlykke Y, Vethe H, Vaudel M, Barsnes H, Berven FS, Tjora E, Raeder H. J Proteome Res. 2015 Jan 2;14(1):521-30. doi: 10.1021/pr500750z. PMID: 25369532


  • Long-term clinical outcome and phenotypic variability in hyperphosphatemic familial tumoral calcinosis and hyperphosphatemic hyperostosis syndrome caused by a novel GALNT3 mutation; case report and review of the literature. Rafaelsen S, Johansson S, Ræder H, Bjerknes R. BMC Genet. 2014 Sep 24;15:98. doi: 10.1186/s12863-014-0098-3. PMID: 25249269
  • Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. Ræder H, McAllister FE, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder MB, Immervoll H, Hoem D, Dimcevski G, Njølstad PR, Molven A, Gygi SP, Kulkarni RN. Diabetes. 2014 Jan;63(1):259-69. doi: 10.2337/db13-1012. PMID: 24062244


  • Severe pancreatic dysfunction but compensated nutritional status in monogenic pancreatic disease caused by carboxyl-ester lipase mutations. Tjora E, Wathle G, Engjom T, Erchinger F, Molven A, Aksnes L, Haldorsen IS, Dimcevski G, Njølstad PR, Ræder H. Pancreas. 2013 Oct;42(7):1078-84. doi: 10.1097/MPA.0b013e3182920e9c. PMID: 23770712
  • Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (maturity-onset diabetes of the young). Ræder H, Vesterhus M, El Ouaamari A, Paulo JA, McAllister FE, Liew CW, Hu J, Kawamori D, Molven A, Gygi SP, Njølstad PR, Kahn CR, Kulkarni RN. PLoS One. 2013;8(4):e60229. doi: 10.1371/journal.pone.0060229 PMID: 23565203
  • Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification. Rafaelsen SH, Raeder H, Fagerheim AK, Knappskog P, Carpenter TO, Johansson S, Bjerknes R. J Bone Miner Res. 2013 Jun;28(6):1378-85. doi: 10.1002/jbmr.1850. PMID: 23325605
  • Derivation of human induced pluripotent stem cells from patients with maturity onset diabetes of the young. Teo AK, Windmueller R, Johansson BB, Dirice E, Njolstad PR, Tjora E, Raeder H, Kulkarni RN. J Biol Chem. 2013 Feb 22;288(8):5353-6. doi: 10.1074/jbc.C112.428979. PMID: 23306198


  • [Tailored medicine or narcissomics?]. Ræder H, Molven A, Njølstad PR. Tidsskr Nor Laegeforen. 2012 Sep 4;132(16):1844-5. doi: 10.4045/tidsskr.12.0582. Norwegian. PMID: 22986961
  • HNF1B mutation in a Turkish child with renal and exocrine pancreas insufficiency, diabetes and liver disease. Gonc EN, Ozturk BB, Haldorsen IS, Molnes J, Immervoll H, Raeder H, Molven A, Søvik O, Njølstad PR. Pediatr Diabetes. 2012 Mar;13(2):e1-5. doi: 10.1111/j.1399-5448.2011.00773.x. PMID: 21767339


  • The role of pancreatic imaging in monogenic diabetes mellitus. Haldorsen IS, Ræder H, Vesterhus M, Molven A, Njølstad PR. Nat Rev Endocrinol. 2011 Nov 29;8(3):148-59. doi: 10.1038/nrendo.2011.197. PMID: 22124438
  • Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease. Johansson BB, Torsvik J, Bjørkhaug L, Vesterhus M, Ragvin A, Tjora E, Fjeld K, Hoem D, Johansson S, Ræder H, Lindquist S, Hernell O, Cnop M, Saraste J, Flatmark T, Molven A, Njølstad PR. J Biol Chem. 2011 Oct 7;286(40):34593-605. doi: 10.1074/jbc.M111.222679. Epub 2011 Jul 22. PMID: 21784842
  • Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study). Hertel JK, Johansson S, Ræder H, Platou CG, Midthjell K, Hveem K, Molven A, Njølstad PR. BMC Med Genet. 2011 Feb 4;12:20. doi: 10.1186/1471-2350-12-20. PMID: 21294870


  1. Pancreatic function in carboxyl-ester lipase knockout mice. Vesterhus M, Raeder H, Kurpad AJ, Kawamori D, Molven A, Kulkarni RN, Kahn CR, Njølstad PR. Pancreatology. 2010;10(4):467-76. doi: 10.1159/000266284. Epub 2010 Aug 19. PMID: 20720448
  2. [Progress in diabetes genetics]. Njølstad PR, Hertel JK, Søvik O, Raeder H, Johansson S, Molven A. Tidsskr Nor Laegeforen. 2010 Jun 3;130(11):1145-9. doi: 10.4045/tidsskr.09.1035. Review. Norwegian. PMID: 20531501
  3. Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Lango Allen H, Johansson S, Ellard S, Shields B, Hertel JK, Raeder H, Colclough K, Molven A, Frayling TM, Njølstad PR, Hattersley AT, Weedon MN. Diabetes. 2010 Jan;59(1):266-71. doi: 10.2337/db09-0555. Epub 2009 Sep 30. PMID: 19794065
  4. Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes. Torsvik J, Johansson S, Johansen A, Ek J, Minton J, Raeder H, Ellard S, Hattersley A, Pedersen O, Hansen T, Molven A, Njølstad PR. Hum Genet. 2010 Jan;127(1):55-64. doi: 10.1007/s00439-009-0740-8. Epub 2009 Sep 17. PMID: 19760265
  5. A case of X-linked hypophosphatemic rickets: complications and the therapeutic use of cinacalcet. Raeder H, Shaw N, Netelenbos C, Bjerknes R. Eur J Endocrinol. 2008 Dec;159 Suppl 1:S101-5. doi: 10.1530/EJE-08-0383. Epub 2008 Sep 5. PMID: 18775977
  6. Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. Vesterhus M, Haldorsen IS, Raeder H, Molven A, Njølstad PR. J Clin Endocrinol Metab. 2008 Sep;93(9):3505-9. doi: 10.1210/jc.2008-0340. Epub 2008 Jul 1. PMID: 18593771
  7. Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. Vesterhus M, Raeder H, Aurlien H, Gjesdal CG, Bredrup C, Holm PI, Molven A, Bindoff L, Berstad A, Njølstad PR. Diabetes Care. 2008 Sep;31(9):1738-40. doi: 10.2337/dc07-2217. Epub 2008 Jun 10. PMID: 18544793
  8. Diagnostic screening of MODY2/GCK mutations in the Norwegian MODY Registry. Sagen JV, Bjørkhaug L, Molnes J, Raeder H, Grevle L, Søvik O, Molven A, Njølstad PR. Pediatr Diabetes. 2008 Oct;9(5):442-9. doi: 10.1111/j.1399-5448.2008.00399.x. Epub 2008 Apr 9. PMID: 18399931
  9. Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Molven A, Ringdal M, Nordbø AM, Raeder H, Støy J, Lipkind GM, Steiner DF, Philipson LH, Bergmann I, Aarskog D, Undlien DE, Joner G, Søvik O; Norwegian Childhood Diabetes Study Group, Bell GI, Njølstad PR. Diabetes. 2008 Apr;57(4):1131-5. doi: 10.2337/db07-1467. Epub 2008 Jan 11. PMID: 18192540 Free Article
  10. Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3. Vesterhus M, Raeder H, Johansson S, Molven A, Njølstad PR. Diabetes Care. 2008 Feb;31(2):306-10. Epub 2007 Nov 5. PMID: 17989309
  11. [50-year-old man with fatigue and monoclonal gammopaty]. Raeder H, Kildahl-Andersen O, Stalsberg H. Tidsskr Nor Laegeforen. 2007 Oct 18;127(20):2677-9. Norwegian. PMID: 17972388
  12. Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians. Johansson S, Raeder H, Eide SA, Midthjell K, Hveem K, Søvik O, Molven A, Njølstad PR. Diabetes. 2007 Dec;56(12):3112-7. Epub 2007 Sep 7. PMID: 17827402 Free Article
  13. Pancreatic lipomatosis is a structural marker in nondiabetic children with mutations in carboxyl-ester lipase. Raeder H, Haldorsen IS, Ersland L, Grüner R, Taxt T, Søvik O, Molven A, Njølstad PR. Diabetes. 2007 Feb;56(2):444-9.
    PMID: 17259390
  14. A hepatocyte nuclear factor-4 alpha gene (HNF4A) P2 promoter haplotype linked with late-onset diabetes: studies of HNF4A variants in the Norwegian MODY registry. Raeder H, Bjørkhaug L, Johansson S, Mangseth K, Sagen JV, Hunting A, Følling I, Johansen O, Bjørgaas M, Paus PN, Søvik O, Molven A, Njølstad PR. Diabetes. 2006 Jun;55(6):1899-903. PMID: 16731861
  15. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Raeder H, Johansson S, Holm PI, Haldorsen IS, Mas E, Sbarra V, Nermoen I, Eide SA, Grevle L, Bjørkhaug L, Sagen JV, Aksnes L, Søvik O, Lombardo D, Molven A, Njølstad PR. Nat Genet. 2006 Jan;38(1):54-62. Epub 2005 Dec 20. PMID: 16369531
  16. [Molecular diagnostics in diabetes mellitus]. Bjørkhaug L, Johansson S, Raeder H, Thorsby PM, Undlien DE, Søvik O, Molven A, Sagen JV, Njølstad PR. Tidsskr Nor Laegeforen. 2005 Nov 3;125(21):2968-72. Review. Norwegian.
    PMID: 16276383
  17. Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. Sagen JV, Raeder H, Hathout E, Shehadeh N, Gudmundsson K, Baevre H, Abuelo D, Phornphutkul C, Molnes J, Bell GI, Gloyn AL, Hattersley AT, Molven A, Søvik O, Njølstad PR. Diabetes. 2004 Oct;53(10):2713-8. PMID: 15448106 Free Article
  18. [Too narrow boot]. Kildahl-Andersen O, Raeder H. Tidsskr Nor Laegeforen. 2004 Aug 12;124(15):1935-7. Norwegian. No abstract available. PMID: 15318409
  19. [Anticoagulation treatment in atrial fibrillation]. Raeder H, Kildahl-Andersen O. Tidsskr Nor Laegeforen. 2002 Feb 28;122(6):651. Norwegian. No abstract available. PMID: 11998724 Free Article
  20. [A man with deep venous thrombosis, transient ischemic attacks and increasing sedimentation rate]. Raeder H, Kildahl-Andersen O. Tidsskr Nor Laegeforen. 2002 Feb 20;122(5):507-10. Norwegian. No abstract available. PMID: 11961981